Welcome to DigitalGlassware

 
 

DigitalGlassware is an innovative cloud-based digital chemistry platform that brings recordability, reproducibility and shareability to your lab at every stage of the discovery process. At the heart of DigitalGlassware is DeviceX (dx), a unique multi-sensor probe that sits right inside the reaction vessel, providing real-time data (temperature, pressure, UV light levels and more), showing exactly what’s going on inside your flask. This data is captured and stored in the cloud alongside each step taken to carry out the reaction, providing a whole new level of insight and understanding.

Over the coming weeks, this blog will show how DigitalGlassware works in real labs, under real reaction scenarios, and how it can save time and money and increase productivity. Whether working in a single site or at institutions across the world, DigitalGlassware is the fastest path to discovery.

For a quick look at the DigitalGlassware online platform follow this link, or continue reading below to find out how the platform assists chemists in the lab.

DeviceX , the unique multi sensor probe able to measure in solution (immersed), the flask head space (exposed) and in ambient conditions.

DeviceX, the unique multi sensor probe able to measure in solution (immersed), the flask head space (exposed) and in ambient conditions.

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Meet Hannah, an academic R&D chemist in Glasgow. Hannah wants to perform a selective amination of an alcohol under mild conditions. After a literature search she came across the use of trichloromethyl ketones as unique reagents for this transformation. To produce the ketone, she identified a suitable alcohol oxidation reaction (Org. Synth. 2018, 95, 310-327).

The scheme for the synthesis of 2,2,2-trichloro-1-phenylethan-1-one.

The scheme for the synthesis of 2,2,2-trichloro-1-phenylethan-1-one.

First, she creates a recipe using the RecipeBuilder (rb) module. This records every reagent, piece of equipment and procedure, step by step, in a standard shareable format.

Hannah constructing a recipe in  DigitalGlassware’s   RecipeBuilder  module.

Hannah constructing a recipe in DigitalGlassware’s RecipeBuilder module.

Next, Hannah sets up the reaction using the hardware that is the key to DigitalGlassware’s unique insights. The EnvironmentalSensor (es) records ambient conditions, while DeviceX (dx) sits inside the flask, continuously recording data such as temperature, UV light levels and even images and sound. Data from external hardware such as stirrer plates can also be recorded. Set-up is simple and the hardware is compact, taking up minimal space in the fume hood. 

DigitalGlassware  in the lab.

DigitalGlassware in the lab.

As Hannah carries out the reaction, the RecipeRunner (rr) tablet app prompts her at every stage, and records the precise time each step is carried out. All the while, real-time data from the hardware is also being logged, showing how each process affects what is happening inside the flask.

After carrying out the reaction twice, and obtaining similar yields of 61% and 69%, Hannah compares the two reaction runs using the RunManager (rm) software. This provides a graphical view of the reaction data from start to finish. In this case the temperature profile of the two reactions can be seen to be very similar.

The  DeviceX  immersed temperature sensor data for the two runs Hannah performed.

The DeviceX immersed temperature sensor data for the two runs Hannah performed.

Future reactions can be compared to these successful runs, giving insight into the reasons for failure - or, as we will see in future posts, giving an early warning if a reaction is not proceeding as it should.

You can view Hannah’s run data and look around some of DigitalGlassware’s software by following this link .

Note all captured reaction data is real as presented. Person’s identities have been anonymised.